![]() Metabolic acidosis can be severe and a pH 7.0.Ĭentral nervous system (CNS) effects in this stage can include headache, lethargy, convulsions, delirium and coma. The prognosis in methanol intoxication depends on the existence of the effects of the formate accumulation and patients who present with severe acidosis, seizure or coma due to the formate have an increased mortality as compared to patients without these signs on presentation. ![]() The latent period is followed by a number of systemic findings as formate accumulates. Clinical effects of methanol intoxication.
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